Pachitariu + Stringer lab
We record tens of thousands of neurons at once in behaving mice, to determine how visual cortex represents the world, how neural responses change during learning, and how those changes arise from underlying synaptic plasticity. We also build and maintain analysis pipelines: Suite2p, Kilosort, Cellpose, Facemap and Rastermap.
Meet us at SfN
We’ll be at SfN, please reach out to connect and come by our posters!
- Sat Nov 14, 1-5pm: Paul LaFosse, LL14, “Raster photostimulation of large-scale neural populations” biorxiv
- Mon Nov 16, 1-5pm: Atika Syeda, C30, “Orofacial behaviors, not eye movements, govern neural activity in mouse visual cortex” (Late-Breaking) biorxiv
- Mon Nov 16, 1-5pm: Miguel Nuñez, AA19, “Linking neural representations to behavior using generalization” biorxiv
- Wed Nov 18, 1-5pm: Ruoxi Sun, CC22, “Disentangling neural plasticity in visual cortex across task, stimulus and contexts”
50,000+ neurons recorded simultaneously at 3 Hz with two-photon calcium imaging, in mouse visual cortex.
Example projects in the lab
How does cortex learn without supervision?
Mice exposed to stimuli with no task and no reward still reorganize their visual representations.
Which visual areas predict how well mice generalize?
Neural discrimination of novel test images, but not of trained images, predicts how well mice generalize.
How much of cortical activity reflects behavior?
Ongoing orofacial movements account for a large fraction of variance across the brain, including in primary sensory areas.
Does cortex predict in space or in time?
Mismatch responses in visual cortex turn out to signal spatial novelty, not violated temporal expectations.
Browse all research, the full publication list, or the raw data.
Recent news
- Miguel Angel Nuñez-Ochoa et al., preprint out on Linking neural representations to behavior using generalization.
- Paul K LaFosse et al., preprint out on Raster photostimulation of large-scale neural populations.
- A critical initialization for biological neural networks published in Nature, with all data and code released.
- Atika Syeda et al., preprint out on Orofacial behaviors, not eye movements, govern neural activity in mouse visual cortex, also presented at Cosyne.
- Lin Zhong et al. on unsupervised pretraining in biological neural networks, published in Nature.